Rosacea is a common chronic inflammatory skin condition that causes redness and visible blood vessels on face. It may also produce small, red, pus-filled bumps. Rosacea can be mistaken for acne, eczema, or a skin allergy.

In US more than 14 million people are estimated living with Rosacea.

What is Rosacea?

Rosacea is a long-term skin condition which results in redness, pimples, swelling, and small and superficial dilated blood vessels and typically affects the face. Most often the nose, cheeks, forehead, and chin are involved.

In some rare cases the oil glands (sebaceous glands) in the nose and sometimes cheeks become enlarged, resulting in a buildup of tissue on and around the nose, a condition known as rhinophyma.

What are the Signs & Symptoms?

Signs include facial redness, small and superficial dilated blood vessels on facial skin, papules, pustules, and swelling.

The following signs & symptoms persist in most cases

  • Flushing (easily blushing)
  • Facial skin hyper-reactivity
  • Persistent redness
  • Pimples, papules, and pustules (Inflammatory rosacea)
  • Inflamed blood vessels (vascular rosacea)
  • Rhinophyma, or excess facial skin around the nose
  • Ocular rosacea
  • Facial swelling

There are several types of Rosacea based on symptoms

  • Erythematotelangiectatic Rosacea – Redness, flushing, visible blood vessels.
  • Papulopustular Rosacea – Redness, swelling, and acne-like breakouts.
  • Phymatous Rosacea – Skin thickens and has a bumpy texture.
  • Ocular Rosacea – Eyes red and irritated, eyelids can be swollen, and person may have what looks like a sty.

With time, people who have Rosacea often see permanent redness in the center of their face.

Cause & Risk factors

The causes of Rosacea are not know but the risk factors are believed to a family history of the condition and environmental factors.

Some of the factors that may potentially worsen the condition include heat, exercise, sunlight, cold, spicy food, alcohol, menopause, psychological stress, or steroid cream on the face, beverages containing caffeine. Some medications and topical irritant are also known to cause Rosacea.

Skin damage due to sun, smoking are some of the other risk factors

Rosacea normally occurs in any age group but most in middle aged women having fair skin.

How it is Diagnosed?

Simple visual inspection by a trained healthcare professional is sufficient for diagnosis of Rosacea and no test is know. People with mild redness Rosacea are never formally diagnosed or treated. When the signs are not prominent then treatments trails are used for confirming diagnosis.

Treatment

There is no cure for Rosacea. Signs & symptoms can be controlled by treatment, generally with some of the antibiotics as oral & in form of creams, eye drops if eyes are effected and laser surgery in some cases, remission is common in Rosacea

The treatments are generally measured as

  • Reduction in facial redness & inflammatory lesions,
  • Number, duration and intensity of flares
  • Decrease in symptoms of itching, burning & tenderness of skin

Avoiding sunlight exposure is recommended, using sunscreen

Some of the medication show improvements and are included in the treatment line such as Ivermectin, Azelaic acid creams, Brimonidine, Doxycycline, and Isotretinoin by mouth. Each category of drug have their own typical mechanism in reducing symptoms

Laser surgery is also used in some conditions that damage the capillary walls and make them absorbed by the body’s natural defence mechanism. Laser treatment may require repeated sessions.

Prevalence of Rosacea

  • Rosacea is most likely to affect fair skinned, Caucasian people but is also seen in people of Asian and African origin.
  • The condition is most common among individuals aged 30 to 50 years and women are two to three times more likely to be affected than men, with women of menopausal age at a greater risk still.
  • Prevalence of Rosacea has been estimated around the world in the range of 0–22%
  • Rosacea is estimated to affect over 14 million people in the US (around 5% of the population)

Feasibility study on Rosacea is ongoing on Credevo.

Would you like to contact these investigators and assess feasibility with them for your clinical trial?

Check details below.

Clinical Trials on Rosacea worldwide

Total Studies

A total of 142 studies are going on Rosacea all around the world with major studies in United States (104), Canada (15), Germany (10) and France (7).


Ongoing studies

A total of 25 studies are On-going in Rosacea with major studies in United States (20), Canada (2) & France (2)

Map of 25 studies found by search of Recruiting, Active, not recruiting Studies | Rosacea

 

Contact Investigators

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Reference

  • https://www.mayoclinic.org/diseases-conditions/rosacea/symptoms-causes/syc-20353815
  • https://en.wikipedia.org/wiki/Rosacea
  • https://www.aad.org/public/diseases/acne-and-rosacea/rosacea#treatment
  • https://www.news-medical.net/health/Rosacea-Epidemiology.aspx

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